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Washington University in St. Louis

April 26, 2002 Vol. 26, No. 30
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Researcher traces gene development in 'last common link'

A researcher studying the last common link between invertebrate and vertebrate animals has found a key genetic change that separates the spineless from the backboned. Full story

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Waterston wins international Gairdner award

56 recipients have gone on to receive Nobel Prize

By Darrell E. Ward

Robert H. Waterston, M.D., Ph.D., director of the Genome Sequencing Center in the School of Medicine, is one of eight scientists to receive the 2002 Gairdner International Award, which this year recognizes exceptional achievement in genomics science. The Gairdner Foundation of Toronto, Canada, announced the awards April 23. Each winner receives $30,000.

Waterston
Robert Waterston
Since 1959, the Gairdner International Awards have been presented to 255 scientists, 56 of whom have gone on to win the Nobel Prize. The award recognizes outstanding contributions by medical scientists whose work will significantly improve quality of life.

Waterston, together with Eric S. Lander, Ph.D., professor of biology at the Massachusetts Institute of Technology and head of the Whitehead Institute Center for Genomic Research in Cambridge, Mass., and Sir John E. Sulston, Ph.D., founder of the Sanger Institute in Cambridge, UK, were recognized for their "major seminal contributions to sequencing of human and other genomes."

Waterston was instrumental in initiating and bringing to fruition the international Human Genome Project, the effort to identify and map the structure of the DNA in every gene of every human chromosome. A draft version of the genome, available to all without constraint, was published in the journal Nature in February 2001. The information provides a genetic blueprint of the makeup of human beings and will help in research to identify the genetic abnormalities responsible for cancer, birth defects and a variety of other human diseases.

In the 1970s and '80s, Waterston, the James S. McDonnell Professor and head of the Department of Genetics in the School of Medicine, helped establish the roundworm, Caenorhabditis elegans, as a powerful experimental organism. Waterston and Sulston subsequently collaborated to successfully sequence the 97 million genetic letters in the worm's DNA. The work marked the first time that all the genes of an organism of more than one cell had been sequenced and mapped and demonstrated the feasibility of sequencing the human genome.

The project also marked the founding of Washington University's Genome Sequencing Center by Waterston. In addition to its work on the international Human Genome Project and the worm genome, the center has played leading roles in the sequencing of numerous other genomes. It also has been a major contributor of expressed sequence tags to public databases.

The award will be presented at the annual Gairdner Foundation dinner, which takes place in October each year and is usually preceded by a national symposium featuring the year's Gairdner International Award winners.


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