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Fatal brain tumors
focus of research

Mouse models of brain tumors may help physicians treat people
with brain tumors. A team in the School of Medicine received
a four-year, $1.2 million grant from the National Institute
of Neurological Disorders and Stroke toward the development
of a model for astrocytoma.
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David Gutmann |
Astrocytomas
are one of the most common types of brain tumor and remain
fatal despite advances in cancer th erapy.
Researchers still are struggling to understand the underlying
genetic events that result in this deadly disease.
Principal
investigator David H. Gutmann, M.D., Ph.D., the Donald O.
Schnuck Family Professor of Neurology, and his colleagues
in the School of Medicine and the University of Toronto
created genetically altered mice that shortly after birth
develop tumors similar to human astrocytomas. The researchers
will use this grant to determine which genetic changes in
these mice are necessary for the development of these tumors
and contribute to their progression.
"Our ability to design targeted therapies for astrocytomas
is heavily dependent on our understanding of the molecular
origins of these tumors," Gutmann said. "Studies that explore
these issues are best done in animal models such as this
one, which will help us develop and test potential treatment
options."
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